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Book
Introduction to the blood-brain barrier : methodology, biology, and pathology
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ISBN: 051157021X Year: 1998 Publisher: Cambridge : Cambridge University Press,

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Abstract

The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.


Book
Talking to the brain at the blood-brain barrier through inflammation-induced prostaglandin E2
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ISBN: 9175191555 Year: 2015 Publisher: Linköping, Sweden : Linköping University,

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Methods in neurosciences.
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ISBN: 9781483288352 1483288358 9780121852917 Year: 1994 Publisher: San Diego, California

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This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.Highlights* Polymeric, cellular, and molecular drug delivery* Neuropharmacology* Blood-brain barrier* Central nervous system


Book
The concept of a blood-brain barrier.
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Year: 1979 Publisher: Chichester Wiley

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Book
Brain barrier systems,
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Year: 1968 Volume: v. 29 Publisher: Amsterdam, New York [etc.] Elsevier Pub. Co.,

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Book
Pénétration des toxiques médicamenteux dans le système nerveux central : cas particuliers des barbituriques
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Year: 1970 Publisher: [S.L. : chez l'auteur],

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Colloquium in biological sciences: blood-brain transfer [4th-1986-New York]
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ISBN: 0897664558 Year: 1988 Publisher: New York NYAS

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Book
The blood-brain barrier in health and disease
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Year: 2017 Publisher: [San Rafael, California] : Morgan & Claypool,

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The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.

Fourth colloquium in biological sciences : blood-brain transfer, held in New York, Nov. 3, 1986
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ISBN: 089766454X Year: 1988 Volume: 529

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Implications of the blood-brain barrier and its manipulation
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ISBN: 0306426285 0306426374 1461280397 1461307015 9780306426377 9780306426285 Year: 1989 Publisher: New York : Plenum Medical Book Co.,

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